Frequency-Specific Alterations of Local Synchronization in Idiopathic Generalized Epilepsy
نویسندگان
چکیده
منابع مشابه
Frequency-Specific Alterations of Local Synchronization in Idiopathic Generalized Epilepsy
Recurrently and abnormally hypersynchronous discharge is a striking feature of idiopathic generalized epilepsy (IGE). Resting-state functional magnetic resonance imaging has revealed aberrant spontaneous brain synchronization, predominately in low-frequency range (<0.1 Hz), in individuals with IGE. Little is known, however, about these changes in local synchronization across different frequency...
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Background: Haptoglobin (Hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. It displays in three common phenotypes, Hp1-1, Hp2-1, and Hp2-2. Proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. Haptoglobin expressed by the Hp2-2 genotype has lower hemoglobin-binding capacity than Hp1-1 or...
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The neurobiological basis of paroxysmal kinesigenic dyskinesia (PKD) is poorly defined due to the lack of reliable neuroimaging differences that can distinguish PKD with dystonia (PKD-D) from PKD with chorea (PKD-C). Consequently, diagnosis of PKD remains largely based on the clinical phenotype. Understanding the pathophysiology of PKD may facilitate discrimination between PKD-D and PKD-C, pote...
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INTRODUCTION In order to explore the mechanism of action of valproate (VPA) in idiopathic generalized epilepsy (IGE), the effect of VPA on cortical EEG activity was investigated. HYPOTHESIS VPA decreases EEG synchronization in the delta and theta frequency bands in a use-dependent manner in IGE patients. METHODS First setting: EEG records of 17 untreated IGE patients (NAE group) were analyz...
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ژورنال
عنوان ژورنال: Medicine
سال: 2015
ISSN: 0025-7974
DOI: 10.1097/md.0000000000001374